It has been shown previously that in normal persons there is a relatively constant relationship between the hematocrit of peripheral venous blood and the circulating red blood cell volume per kilogram of body weight (CRBCV/kg.). In these instances the hematocrit is a useful and practical indicator of the size of the erythron. However, in patients with polycythemia vera and in certain persons in whom the peripheral hematocrit is abnormally high, this relationship was found to be unreliable.1 The ratio, hematocrit of peripheral venous blood divided by CRBCV/kg. , gives an indication of the relative error of the hematocrit which may be spuriously normal, elevated, or low.In the present study this relationship was determined in patients with Addisonian pernicious anemia in relapse, during regeneration in response to specific therapy, and in remission. It was found in patients who were in hematologic relapse that the venous hematocrit correlated poorly
RABINER SF, LICHTMAN HC. Studies on the Relationship Between the Peripheral Blood Counts and the Total Body Red Cell Volume: II. In Patients with Addisonian Pernicious Anemia in Relapse, During Recovery, and in Remission. AMA Arch Intern Med. 1957;99(3):474–480. doi:10.1001/archinte.1957.00260030156015
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