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March 1957

Paper Electrophoresis.

AMA Arch Intern Med. 1957;99(3):492-494. doi:10.1001/archinte.1957.00260030174021

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Interest in the techniques of paper electrophoresis has shown a phenomenal growth. From a mere handful of references in the 1940 Decennial Index and Chemical Abstracts the bibliography has increased to about 5000 references at the present writing. No end is in sight. Paper electrophoresis has been applied to separations of metallic ions, viral particles, and nearly everything between these limits of size and complexity. Almost as impressive as its versatility is its simplicity in practise. Even more amazing is the low cost of adequate equipment, which can be assembled by any "do-it-yourself" scientist. More sophisticated versions provide for two-dimensional separations, for continuous separations, for combinations of electrophoresis with column chromatography, and for such virtuosities as Kolin's multigradient procedures, which resolve certain mixtures in a matter of seconds. By application of isotopic labels, by specific chemical reagents, by staining with dyes, or by simple elution procedures the separated components of

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