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April 1957

Serum Transaminase as a Diagnostic Aid

AMA Arch Intern Med. 1957;99(4):556-568. doi:10.1001/archinte.1957.00260040056006

Glutamic oxaloacetic transaminase, an enzyme which catalyzes the reversible transamination reaction by which glutamate and oxaloacetate interact to form aspartate and α-ketoglutarate, is present in high concentration in a number of animal tissues, but most notably in heart, liver, kidney, muscle, and brain.1

The serum or plasma level of glutamic oxaloacetic transaminase, henceforth referred to as transaminase in this report, has recently come into prominence as a diagnostic aid in clinical medicine.2-11 Following the initial observations by Karmen, Wróblewski and LaDue that all normal human sera contain transaminase activity and the development by Karmen of a simple technique for the quantitative assay of serum transaminase,3 LaDue and his associates demonstrated that acute cardiac, hepatic, and skeletal muscle necrosis in man was associated with a significant rise in the level of serum transaminase activity.2,4,5 These initial observations have been confirmed both in man 7-11 and under experimental conditions