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April 1957

Leukocyte Agglutinins in Human Sera: Correlation Between Blood Transfusions and Their Development

Author Affiliations

San Francisco

From the Department of Medicine, Stanford University School of Medicine.

AMA Arch Intern Med. 1957;99(4):587-606. doi:10.1001/archinte.1957.00260040087010

Introduction  The discovery of autoantibodies for erythrocytes in acquired hemolytic anemia (AHA)* and for platelets in idiopathic*The following abbreviations will be employed throughout this paper: PVP, polyvinylpyrrolidone; ITP, idiopathic thrombocytopenic purpura; DLE, disseminated lupus erythematosus; PMN, polymorphonuclear leukocyte; TEPA, triethylene phosphoramide; PTC, plasma thromboplastin component deficiency; PNH, paroxysmal nocturnal hemoglobinuria; AHA, acquired hemolytic anemia.thrombocytopenic purpura (ITP) led to a search for antibodies for leukocytes in leukopenic persons. The observation by Moeschlin and Wagner in 19521,2 of the presence of a leukoagglutinin in the serum of a patient with granulocytopenia following aminopyrine (Pyramidon) administration introduced a series of publications demonstrating agglutinins for leukocytes in human sera and the antigens of leukocytes. 3-23The contributions of these studies were (1) the development of relatively simple techniques for the detection of leukoagglutinins, (2) a limited survey of disorders in which leukoagglutinins may be found, (3) a brief description of the