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May 1957

High Blood Pressure: A New Approach to Its Management

Author Affiliations

New York

New York Medical College, Metropolitan Medical Center.

AMA Arch Intern Med. 1957;99(5):833-839. doi:10.1001/archinte.1957.00260050161019

This exhibit presents a graphic report on two studies, both of which were designed to evaluate chlorpromazine hydrochloride and Rauwolfia serpentina used in combination. The first study is an extensive investigation of the combination in the treatment of 350 hypertensive patients; the second, a preliminary trial of the combination in 50 neuropsychiatric patients.

Hypertensive Study  Unfortunately there is no safe, effective single drug for the treatment of moderate and severe hypertension. The potent drugs commonly used in these conditions (hexamethonium, pentolinium, the veratrums, hydralazine, et al.) are fairly unpredictable in action, and because the margin between their effective and toxic dose is small, the side-effects which they cause are numerous, annoying, and not infrequently dangerous.Rauwolfia serpentina, an agent capable of producing a slow, gradual lowering of blood pressure, has been found valuable in treating mild hypertension. Chlorpromazine, which often exerts an immediate, slight hypotensive affect as a hypotensive agent,

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