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June 1957

Syphilis: Review of the Recent Literature

Author Affiliations

Philadelphia With the Collaboration of T. Guthe, M.D., and C. J. Hackett, M.D., Geneva, Switzerland

From the University of Pennsylvania Department of Dermatology, School of Medicine (Dr. Pillsbury, Professor), and Graduate School of Medicine (Dr. Beerman, Chairman), and from the Venereal Disease Control Section, Division of Preventive Medicine, Philadelphia Department of Public Health (Dr. Lentz, Chief).

AMA Arch Intern Med. 1957;99(6):932-954. doi:10.1001/archinte.1957.00260060090009

Clinical Manifestations  Much new material on clinical syphilis has been reported on during this review period. The chief interest, however, has centered on the later aspects of the disease, notably cardiovascular.

Early Syphilis.  —Richter 113 analyzed the time of infection of 257 females with primary and secondary syphilis in relation to the phase of the menstrual cycle. The fewest infections were seen late in the menstrual cycle when corpus luteum hormone was at its height. The largest number of infections were seen in the early part of the cycle when follicular hormone was elevated.

Alopecia Areata Due to Syphilis.  —Behrman and Wild 114 reported in detail a case of alopecia areata which they ascribed to syphilis. In our opinion, their diagnosis must be questioned, since their patient lacked all other manifestations of secondary syphilis and their report did not include any data on the response to

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