The phenomenon of ketosis has intrigued physicians and biochemists ever since the ketone bodies, acetoacetic acid, β-hydroxybutyric acid, and acetone were identified almost 100 years ago in the urine of patients with diabetic acidosis.1 The decade beginning in 1930 marked the opening of a period of intense interest in the role of the endocrines in ketosis, sparked by the almost simultaneous discovery and investigation of the ketogenic activity of certain pituitary extracts by Burn and Ling,2 Anselmino and Hoffman,3-5 Black, Collip, and Thomson,6 and Rietti.7-10 Especially noteworthy during this period was the work in the laboratories of Houssay,11-13 Long,14-16 Mirsky,17-20 Somogyi,21,22 and Stadie.23 Progress in this field was impeded to some degree, however, by methodological difficulties, by lack of availability of purified hormones, and by large gaps in knowledge concerning the details of the metabolic processes involved in fat catabolism and anabolism and in ketogenesis itself. Thanks to the brilliant
ENGEL FL. The Influence of the Endocrine Glands on Fatty Acid and Ketone Body Metabolism. AMA Arch Intern Med. 1957;100(1):18–33. doi:10.1001/archinte.1957.00260070032003
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