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July 1957

Central Nervous System Sarcoidosis Successfully Treated with Prednisone

Author Affiliations

Richmond, Va.

From the Medical Service, Veterans' Administration Hospital.

AMA Arch Intern Med. 1957;100(1):139-142. doi:10.1001/archinte.1957.00260070153018

Sarcoidosis is defined as a chronic indolent and benign disease of unknown cause involving skin, lymph nodes, eyes, salivary glands, lungs, and bones of the hands and feet.1 It is also well known that sarcoidosis can involve practically every organ system of the body, including the central nervous system.2,3 The incidence of nervous system involvement in this disease is estimated between 1% and 5%, with lesions commoner in peripheral and cranial nerves than in the central nervous system.2,4,5 Colliver, Hook, and Meyer et al. discuss the problem of nervous system sarcoidosis but do not report any cases treated with steroid hormones.2,4,6 Pennell reported two cases of central nervous system sarcoidosis treated with corticotropin (ACTH) and cortisone without beneficial effect.7 Olsen, on the other hand, discussed a case of sarcoidosis with Bell's palsy and spinal fluid changes treated with corticotropin and streptomycin with rapid recovery.8 On review of the literature, we

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