Plasma thromboplastin antecedent (PTA) deficiency was first described by R. L. Rosenthal et al., in 1953,1 as a mild to moderately severe hereditary hemorrhagic disease resembling hemophilia but occurring in both males and females. Further studies by the same group revealed fairly well-defined distinctions between antihemophilic globulin (AHG), plasma thromboplastin component (PTC), and PTA.2 Only a few subsequent cases of PTA deficiency have been reported.3,4 The present report deals with a family in which a coagulation disorder, eventually diagnosed as PTA deficiency, was found.* Both males and females were affected, inheritance taking place either through males or females. Of the 10 members of the family available for study, 5 showed indications of the disease (Fig. 1). However, the variability in laboratory tests indicated a somewhat less well-defined character of the deficient factor than is found in either the AHG or the PTC coagulation defect. In the case
CAMPBELL EW, MEDNICOFF IB, DAMESHEK W. Plasma Thromboplastin Antecedent (PTA) Deficiency. AMA Arch Intern Med. 1957;100(2):232–240. doi:10.1001/archinte.1957.00260080058012
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.