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August 1957

Alterations in Cardiac Output Following the Intrajejunal Administration of Hypertonic Solutions: Significance of These Changes in the Dumping Syndrome

Author Affiliations

New York

From the Division of Experimental Surgery, the Andre and Bella Meyer Physiology Laboratory of the Sloan-Kettering Institute, and the Departments of Surgery and Medicine, Memorial Center and Cornell University Medical College. Supported by U. S. P. H. S. Grant CS-9261.

AMA Arch Intern Med. 1957;100(2):255-258. doi:10.1001/archinte.1957.00260080081015

After resection of the stomach, many patients experience difficulty in maintaining an adequate nutritional status. They are often unable to assume their preoperative activities despite good control of their primary disease. This applies to peptic ulcer patients as well as to cancer patients. Part of the difficulty is due to an incapacitating group of symptoms which many of the patients experience after eating and which has been referred to as the "dumping," or "postgastrectomy," syndrome. The syndrome consists of gastrointestinal, vasomotor, and emotional disturbances which begin 15 to 20 minutes after eating and are characterized by a sensation of epigastric fullness, anxiety, weakness, sweating, tachycardia, tachypnea, pallor, and hypotension.

In 1953, Roberts et al.,1 working with patients as well as dogs, postulated a mechanism for the dumping syndrome and offered objective criteria for its diagnosis. It was suggested that certain food substances induce an acute shift of extracellular water