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August 1957

Thrombotic Thrombocytopenic Purpura: A Report of Two Cases

Author Affiliations


From the Medical Services of the Veterans Administration Hospital and Nazareth Hospital. Resident in Medicine.

AMA Arch Intern Med. 1957;100(2):276-279. doi:10.1001/archinte.1957.00260080102020

Thrombotic thrombocytopenic purpura (TTP) is a rare disease of unknown etiology. It is known by a number of synonyms, of which TTP is the most widely accepted. It is characterized by the triad of thrombocytopenic purpura, severe hemolytic anemia, and neurological signs of bizarre and transitory nature. Less than 100 cases have been reported. The original description of the disease was made by Moschcowitz, in 1925,1 although a clearer delineation with clincopathological correlation was reported by Baehr et al., in 1936.2 Two excellent reviews have been published recently.3,4

The following report is of two cases seen recently.

Report of Cases 

Case 1.  —A 35-year-old white, married, postal employee was admitted to the Veterans Administration Hospital on Sept. 10, 1954. He had a history of chronic dermatitis for approximately 20 years. Since December, 1953, he had noted bleeding of the nose and gums, easy bruising, and purpura. Three