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August 1957

External Manifestations of Multiple Polyposis: Report of a Case with Negative Family History

Author Affiliations

U. S. N. B. Air Force

From the Departments of Medicine and Radiology, 3275th U. S. Air Force Hospital, Parks Air Force Base, Calif. Now Assistant Resident in Medicine, Michael Reese Hospital, Chicago (Dr. Lazar); Chief, Department of Radiology (Capt. Crow), and Assistant Chief, Department of Radiology (Capt. Brogdon).

AMA Arch Intern Med. 1957;100(2):290-295. doi:10.1001/archinte.1957.00260080116023

The constantly intriguing prospect of recognizing an internal malignancy or premalignant lesion by seemingly unrelated external pathological processes received additional attention with the description by Gardner of a familial syndrome consisting of multiple polyposis, osteomatosis, and skin tumors.1-3 Discovery of this triad in an Army enlisted man led to a diligent family investigation in which we failed to find any members of the kindred similarly afflicted at the present time. This case, then, is being reported as an apparently isolated classic example of this syndrome, the recognition of which may prove to be a genuine advance in cancer prevention.

Report of Case  A 25-year-old Caucasian Army private was admitted to the 3275th U. S. Air Force Hospital at Parks Air Force Base, Calif., on Oct. 29, 1956, after having been seen in the medical clinic, where a diagnosis of polyposis had been established by rectal examination. The patient complained