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August 1957

Terramycin (Oxytetracycline).

AMA Arch Intern Med. 1957;100(2):337. doi:10.1001/archinte.1957.00260080163037

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The first part of this review deals with the physical and chemical properties of Terramycin, its pharmacology, and its antimicrobial activity. The remainder of the book is devoted to the treatment of various types of infection in the different systems of the body. In general, it is uncritical, though a large amount of information is contained in it. Little-known points, such as the interference with absorption of the drug produced by aluminum hydroxide gels, are emphasized. The combination of judicious surgery with Terramycin treatment is stressed. Not enough emphasis, on the other hand, is given to the increasing resistance of many organisms, such as staphylococci (up to 80%), to this agent, and a scant two pages are devoted to resistance and reactions, with practically no mention of staphylococcal diarrhea as a complication. The book tries to sell Terramycin rather than critically appraise it, and for this reason it is not

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