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September 1957

The Correction of a Hemorrhagic Diathesis in Preparation for Surgery: The Correction of Plasma Thromboplastin Antecedent Deficiency

AMA Arch Intern Med. 1957;100(3):474-477. doi:10.1001/archinte.1957.00260090130018

The preoperative preparation of patients manifesting a systemic hemorrhagic diathesis has always presented the physician with a serious and often difficult problem. Very few reports dealing with the correction of the coagulation defect of plasma thromboplastin antecedent (PTA) deficiency are to be found in the literature. Rosenthal et al. have been able to correct the PTA deficiency of some patients with a single transfusion of 500 cc. of seven-day-old plasma.1,2 The correction, as measured by in vitro techniques, persisted for seven days in one patient. Another patient was normalized for 24 hours after infusion of only 50 cc. of plasma.3

The patient reported in this article required transfusions of large amounts of blood for correction of the in vitro test. This patient was previously reported from this department as a well-documented case of PTA deficiency.4

Methods  The routine hematologic tests were performed with the usual methods.