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Article
October 1957

Clinical and Laboratory Observations on Chlorothiazide (Diuril): An Orally Effective Nonmercurial Diuretic Agent

Author Affiliations

Houston, Texas With the Technical Assistance of Ann Alexander, Carol Marsh, and Jean Gaffney

From the Departments of Medicine and Pharmacology, Baylor University College of Medicine, and the Veterans' Administration Hospital.

AMA Arch Intern Med. 1957;100(4):582-596. doi:10.1001/archinte.1957.00260100066008
Abstract

Chlorothiazide* is a compound whose properties make it valuable in cases where it is desirable to increase the elimination of sodium, chloride, and water. It is a nonmercurial orally active compound1 which produces a broad spectrum of electrolyte excretion effects and a diuretic effect equal to or greater than that seen following the administration of currently available oral diuretics.

This report presents data on the compound concerning its effect in man and the laboratory dog on the excretion of water and electrolytes, the relationship of dosage to the increase in sodium excretion, the onset and duration of its action after oral and parenteral administration, its clinical efficacy, and the comparative potency as a diuretic agent as compared to various diuretics which are already available.

Methods and Materials 

A. Laboratory Observations.  —The acute diuretic response to chlorothiazide was observed in 34 dogs. Thirty-two studies were done using unhydrated dogs (Group I),

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