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October 1957

Progressive Diffuse Interstitial Fibrosis of the Lungs (Hamman-Rich Syndrome): Report of a Case of Seven Years' Duration

Author Affiliations

Redwood City, Calif.

From the Medical Service and Laboratory of the Sequoia Hospital, Redwood City, Calif., and the Department of Pathology, University of California School of Medicine, San Francisco.

AMA Arch Intern Med. 1957;100(4):651-657. doi:10.1001/archinte.1957.00260100135017

Since Hamman and Rich,1 in 1944, first described the syndrome now bearing their names, a number of similar cases have been reported. The present report of an additional case seems warranted because of a known duration of seven years with clinical and radiological observations and because of an associated hyperglobulinemia and pathological cardiac, renal, and splenic lesions.

Report of Case 

History.  —A 42-year-old white housewife of French extraction was first seen in March, 1947, because of fatigue and amenorrhea of two months' duration. She gave a history of several common childhood diseases. There had been no operations or injuries. The family history was noncontributory. There was no history of exposure to industrial dusts or chemicals.In 1927, the patient was hospitalized in a sanatorium. A diagnosis of pulmonary tuberculosis, Stage I, was made. The record did not disclose whether or not a positive sputum had been found or whether