The cooperative effort of three groups of investigators made it possible to study the clinical course and the metabolic and hormonal derangement of a patient with adrenal carcinoma and the responsiveness of the tumor to hormone stimulation and Amphenone (1,2-bis[p-aminophenyl]-2-methylpropanone-1-dihydrochloride) t h e r a p y.1-5 This study covers a period of four years during which three stages of the course of Cushing's syndrome were investigated. The first stage illustrates the presence of significant hormonal and metabolic aberrations, although there was a paucity of clinical signs and symptoms. The second stage, which followed the removal of an adrenal tumor, illustrates the reversibility of Cushing's syndrome in both clinical and biochemical parameters. This remission, considered to be a "cure," lasted, however, only approximately three and one-half years. It was interrupted by the sudden emergence of pronounced virilization associated with significant hormonal and metabolic aberrations. This third stage
SPENCER H, LEWIN I, LASZLO D, HERTZ R, KAPPAS A, GALLAGHER TF. Adrenocortical Carcinoma with Hyperadrenocorticism: A Clinical, Metabolic, and Hormonal Study. AMA Arch Intern Med. 1957;100(4):658–668. doi:https://doi.org/10.1001/archinte.1957.00260100142018
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