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November 1957

Pathological Changes Noted in Bone Marrow in a Case of Q Fever

Author Affiliations

Fresno, Calif.

From the Laboratory and Medical Services, Veterans' Administration Hospital, Fresno, Calif. Clinical Assistant Professor of Pathology, Baylor University College of Medicine, Houston, Texas (Dr. Ende).

AMA Arch Intern Med. 1957;100(5):793-796. doi:10.1001/archinte.1957.00260110109015

The known pathological changes in Q fever are sparse and relatively nonspecific. The most conspicuous pathological findings are confined to the lung,1 and, although recently granulomas have been described in the liver,2 in general other organs show even less specific findings.

In a fatal case of Q fever the bone marrow has been described as showing an increase in fat and a depression of the myeloid element,3 while in another case it was found to have a relatively normal erythromyelopoietic series.1 Lillie et al. have described small nodules of lymphocytes and "vague nodules of epithelioid cells and fragmenting leukocytes in the splenic pulp and bone marrow of monkeys." 1

Recently, in sections made from a bone marrow clot in a case of Q fever, the authors encountered changes believed to be an angiitis.

Report of a Case  A 32-year-old white man entered the hospital on Feb.

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