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November 1957

Saturnine Gout: A Secondary Type of Gout

AMA Arch Intern Med. 1957;100(5):802-812. doi:10.1001/archinte.1957.00260110118017

A century has elapsed since Sir Alfred B. Garrod first emphasized the relationship between chronic lead intoxication and the development of gout.1,2 Many of the early authorities were impressed with this association of diseased states, and the term "saturnine gout" gained wide acceptance. Duckworth 3 states that the first report of coexistent gout and plumbism was made, unknowingly, by Musgrave, in 1703. Brouardel4 credits Skagge with observing gout in lead workers as early as 1764. Lüthje 5 in 1896, in a very complete review of the literature up to that time lists a number of scattered case reports in which plumbism and gout coexisted. Garrod, himself, in the third edition of his book,6 acknowledges the priority of others in reporting this concomitance of diseases. However, all subsequent authors agree that it was Garrod who first clearly emphasized the high incidence of plumbism in gouty subjects and suggested