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December 1957

The Search for an Experimental Counterpart of Pernicious Anemia: The George Minot Lecture

Author Affiliations

Salt Lake City

AMA Arch Intern Med. 1957;100(6):862-869. doi:10.1001/archinte.1957.00260120006002

I find it a particularly pleasant opportunity to give this, the seventh Minot Lecture because George R. Minot's Nobel Prizewinning discovery of the value of liver therapy in pernicious anemia was announced as my own career in medicine began and did much to shape my interests and course. As an intern, in 1925-1926, I observed the dramatic effect of this discovery on the lives and well-being of patients on our wards who but a few weeks before seemed to be doomed to inevitable death. Furthermore, later as an instructor at The Johns Hopkins Hospital attempting to delve into some of the problems of hematology, I found Dr. Minot's occasional visits stimulating and his little notes of encouragement when some paper of mine appeared in print genuinely inspiring. To Minot, the inquisitive student of disease, who worked with dogged determination in spite of his own ill health, to the biologist whose

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