The presence of a pepsin-like entity in the urine has been known for almost a century; Brücke 1 first mentioned it in 1861, Frouin 2 described it in 1904, and Gottlieb3 further added to its understanding in 1924. It remained dormant until 1946, when Farnsworth 4 published a review of the literature, with comments on the absence of this pepsinlike substance in the urine of perniciousanemia patients. The following year, Bucher 5 evaluated the effects of varied diets on this urinary substance, now termed "uropepsin," hereafter referred to as U-P (the end-product of uropepsinogen activation). The last decade has seen a renewed interest in U-P studies, further intensified by the impact of Selye's "Adaptation Syndrome" and the emergence of endocrinology from its early theoretical stage to the maturity of the corticotropin-cortisone era, and strengthened by innumerable practitioners who would spare their patients the discomforts of the stomach tube.
ROSENBERG SJ. Uropepsin Excretion: Studies in Three Hundred Patients. AMA Arch Intern Med. 1957;100(6):937–942. doi:10.1001/archinte.1957.00260120081009
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