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January 1958

Adenovirus Vaccine: Development, Field Evaluation, and Appraisal of the Need for Vaccination in Military and Civilian Populations

Author Affiliations

Washington, D. C.

Department of Respiratory Diseases, Walter Reed Army Institute of Research.

AMA Arch Intern Med. 1958;101(1):47-53. doi:10.1001/archinte.1958.00260130061005

Background  The acute respiratory illnesses caused by adenoviruses (RI-APC-ARD)1-3 constitute a major problem in military medicine. These agents are the cause for the majority of cases of acute respiratory illness among new recruits in the Armed Forces.4-8 By contrast, adenovirus-caused respiratory disease is relatively infrequent among the "seasoned" cadre, and this is true also of the adult civilian population.The respiratory illnesses caused by adenoviruses fall into the general syndromes of febrile catarrh, undifferentiated acute respiratory disease (ARD), nonstreptococcal exudate pharyngitis, atypical pneumonia unassociated with the development of cold agglutinins, and pharyngoconjunctival fever.9-11 More commonly, these illnesses are referred to as catarrhal fever, grippe, acute pharyngitis, "severe colds," or virus pneumonia. The adenoviruses have not been associated etiologically with the common cold.9,12 At least 14 distinct immunological types of adenovirus have been recognized up to the present.13 Only three of these, however, namely, Types 4, 7, and 3,

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