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January 1958

Further Clinical and Investigative Uses of Liver Biopsy: An Analysis of Five Hundred Twenty-Seven Biopsies

Author Affiliations

Jamaica, B. W. I.

From the Departments of Medicine, Pathology, and Biochemistry of the University College of the West Indies and the Tropical Metabolism Research Unit of the Medical Research Council.

AMA Arch Intern Med. 1958;101(1):67-83. doi:10.1001/archinte.1958.00260130081008

It is no longer a matter of controversy whether needle biopsy of the liver is a justifiable procedure in clinical medicine. Most authorities agree that the advantages of its discriminative use outweigh its dangers, and in experienced hands with proper precautions the risk to the patient is almost negligible. The number of excellent reports on liver biopsy that have appeared in recent years, particularly those by Sherlock,1 Gillman and Gillman,2 Hoffbauer,3 Schiff,4 and Popper and co-workers,5 underline the increasing importance of this procedure and its contribution to the study of liver disease. It has so far had its widest application clinically and has become one of the main diagnostic tools in the differential diagnosis of a wide range of liver diseases. Zamcheck and Sidman 6 have recently listed a number of other diseases not primarly hepatic in origin in which liver biopsy has been usefully

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