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January 1958

Drug-Dependent Coombs (Antiglobulin) Test and Anemia: Observations on Quinine and Acetophenetidin (Phenacetin)

Author Affiliations

Dallas, Texas

From the Departments of Pathology and Medicine, The University of Texas Southwestern Medical School.

AMA Arch Intern Med. 1958;101(1):87-96. doi:10.1001/archinte.1958.00260130101010

The Coombs (antiglobulin) test as applied to erythrocytes has been especially of value in the identification and study of isoimmune states1,2 and in acquired hemolytic anemia3,4 in which an autoimmune state has been proposed.5,6 Recently Harris7 described an additional application of the Coombs test to erythrocytes which was dependent on humoral factors in the patient's serum plus the trivalent antimony compound stibophen (Fuadin). This phenomenon, associated with a hemolytic state due to multiple contacts by the patient with the drug stibophen, may be compared with the drug-dependent agglutination of platelets described by Ackroyd 8,9 in the thrombocytopenia induced by allylisopropylacetylcarbamide (Sedormid) and varified for quinidine 10-12 and quinine.13 It is also of interest that the agglutination of leukocytes dependent on serum factors and a drug, similar to Ackroyd's phenomenon for platelets, has been described.14

In the present report we wish to record the encounter of a positive Coombs test for

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