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February 1958

Characteristics of Influenza Virus Infections Observed in St. Louis from 1943 to 1957: I. Relationship of Changes in Antigenic Composition of Influenza Viruses to Morbidity from Influenza

Author Affiliations

St. Louis

From the Miller Pulmonary Laboratory of the Department of Internal Medicine, St. Louis University School of Medicine.

AMA Arch Intern Med. 1958;101(2):203-210. doi:10.1001/archinte.1958.00260140035007

The recent occurrence of extensive influenza epidemics in the Far East and the spread of the infection to this country and other parts of the world has aroused new interest in the epidemiology of this disease. A long period of freedom from serious influenza outbreaks has been interrupted by the appearance of a virus strain of sufficient virulence to produce a high morbidity in areas in which it appears, although the accompanying mortality rate fortunately remains low. The continuous investigations of the U. S. Armed Forces Commission on Acute Respiratory Disease and the Influenza Study Program of the World Health Organization prepared the background for an appraisal of the characteristics of the new virus strain very quickly after its isolation and allowed an estimate to be made of the danger it presents of causing extensive epidemics.

The Virus Laboratory of the Department of Internal Medicine of St. Louis University has

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