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February 1958

Binding of Corticosteroids by Plasma Proteins: V. Corticosteroid-Binding Globulin Activity in Normal Human Beings and in Certain Disease States

Author Affiliations

St. Louis

From the Metabolism Division, Department of Medicine, Washington University School of Medicine, and Barnes Hospital.

AMA Arch Intern Med. 1958;101(2):286-290. doi:10.1001/archinte.1958.00260140118017

The role of the blood plasma in the transport of nutrients, metabolic intermediates, and hormonal agents has long been recognized, yet there is now an increasing awareness of the degree to which plasma proteins may be specialized for this function. Uniquely adapted proteins are responsible for the transport of nearly all the neutral fat, cholesterol, and phospholipids of the plasma in colloidal solution.1 The free fatty acids of plasma, which have recently been shown to be of great importance in fat transport from the peripheral depots to the sites of oxidation, circulate nearly completely bound to the plasma albumin.2 Albumin also binds many other substances of physiologic significance. Most of the circulating iron of the plasma is bound to an iron-binding globulin.3 The degree of binding of thyroxine to a thyroxine-binding protein is well known and is made the basis of the familiar clinical index of thyroid

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