Since the beginning of the awareness of the acute radiation syndrome which followed accidents in this country and the meager knowledge concerning the effects of the atomic bomb at Nagasaki and Hiroshima many attempts have been made to abort the syndrome by various means. Jacobson's1 experiments in shielding certain of the hematopoietic organs and, later, Cole's2 work in replacing the damaged cells with emulsified spleen pulp gave the earliest good results.
Lorenz3 later began replacing the damaged bone marrow cells with similar undamaged cells.
Early in this work the mechanism of activity of the shielded spleen and transplanted cells brought about two hypotheses: (1) that humeral effects brought about the improvement and (2) that the transplanted cells were able to proliferate and mature and in the end bring about repopulation of the damaged organs of hematopoiesis.
In a review of the work on bone marrow transplantation, Congdon
MILLER FR. The Mechanism of Bone Marrow Repopulation. AMA Arch Intern Med. 1958;101(2):312–314. doi:10.1001/archinte.1958.00260140144022
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