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February 1958

The Sensitivity of Staphylococci to Antibiotics: A Five-Year Study of Sensitivity, Usage, and Cross Resistance in a General Hospital

Author Affiliations

Milwaukee With the Technical Assistance of Carl L. Strelitzer, Ph.B.

From the infectious disease control unit of the Department of Medicine of the Milwaukee County General Hospital and Marquette University School of Medicine; Assistant Clinical Professor of Medicine, Marquette University School of Medicine (Dr. Waisbren).

AMA Arch Intern Med. 1958;101(2):397-406. doi:10.1001/archinte.1958.00260140229033

The purpose of this report is to present data regarding the sensitivities and cross resistances of staphylococci to antibiotics in a manner that will be of maximum use and interest. In addition, certain fundamental conclusions regarding the influence of chemotherapy on the resistance of bacteria that are suggested by these data will be considered.

The current problem of infections due to staphylococci has been the subject of numerous publications, and several authors have commented upon the need for precise longterm epidemiological studies of staphylococci which might help delineate mechanisms of changing resistances to antibiotics and also which might point the way to logical solutions of this problem.1-6 The present study was begun in 1952 at the Milwaukee County General Hospital, and since that time 500 patients with staphylococci infections have been studied at the bedside and through in vitro tests of the organisms isolated from them. The clinical pictures