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March 1958

Mechanisms of Hypertension, with a Consideration of Atherosclerosis.

AMA Arch Intern Med. 1958;101(3):677. doi:10.1001/archinte.1958.00260150165029

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This is a fascinating book about a subject of much controversy. It is bursting with ideas, full of provoking thoughts, and generously sprinkled with Schroeder's theories, guesses, and personality.

The book is divided into sections in which the author comments on the mechanisms of production of hypertension, develops hypotheses about causes of essential arterial hypertension, theorizes on the importance of trace metals in the development of arterial hypertension and atherosclerosis, and discusses the therapy of hypertensive disease. A section is devoted to the treatment of atherosclerosis, but this might have been kept on the drawing boards, for the method of therapy suggested has only theoretical value and has not been proved in clinical trial.

Much of the book is devoted to a discussion of known biochemical alterations in essential arterial hypertension and an examination of theories which might explain the changes. Although Schroeder is usually careful to label his theories

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