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May 1958

The Concept of Early Diagnosis in Strokes: ROBERT G. SIEKERT, M.D., and CLARK H. MILLIKAN, M.D., Rochester, Minn.

AMA Arch Intern Med. 1958;101(5):872-880. doi:10.1001/archinte.1958.00260170028005

Cerebrovascular disease remains as an important medical problem. Cerebral infarction is the common variety and, when extensive, defies adequate treatment or functional replacement. Prevention of such damage to the brain would be one approach to this serious problem. In the absence of specific measures for the prevention of cerebral atherosclerosis, attention need be drawn to means that can be utilized to anticipate and thereby possibly prevent the occurrence of selected varieties of strokes. The purpose of the present paper is to discuss certain early symptoms, their pattern and their significance, and their role in this early recognition. Thus, in carefully chosen instances of cerebrovascular disease, treatment might be instituted prior to the development of massive cerebral damage. A report on a method of treatment with use of anticoagulant drugs in these symptom-complexes has been given elsewhere.1

The differential diagnosis of the three commonest types of cerebrovascular disease —thrombosis, embolism,

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