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May 1958


AMA Arch Intern Med. 1958;101(5):1009. doi:10.1001/archinte.1958.00260170165018

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Guided no doubt by the famous statement of Cruveilhiers "La phlébite domine en quelque sorte la pathologie tout entiére," which he quotes in the summary, Professor Perlick in his monograph presents the broad aspects of thromboembolism as the background for his main topic: anticoagulants. A fairly detailed discussion of the coagulation reaction, including many of the newest concepts and proposed factors, serves as the introduction. This is followed by a comprehensive account of the common anticoagulants. It includes the biochemistry, physiological action, toxicity, therapeutic indication, and control.

A section devoted to the nervous and hormonal factors in their relation to blood coagulation is stimulating and informative, as is to be expected, since Professor Perlick himself has been an important contributor to this field. Unfortunately, a little too much importance is attached to the significance of the clotting time. The meticulous review of the old literature is of dubious value. Thus,

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