Several years ago, a striking advance in radiologic examination of the biliary tract enabled the common duct to be visualized by a new solution administered intravenously.1 Shortly thereafter it was learned that the biliary tract could be outlined in the absence of the gallbladder.2 This new technical accomplishment was made possible by a rather highly concentrated iodine derivative, prepared as a solution and administered intravenously. Iodipamide (Cholografin) methylglucamine is a colorless solution of the bis N-methylglucamine salt of 3-3'(adipoyldiimino) bis (2,4,6-triiodobenzoic acid). Since its introduction, different techniques have been employed in order to obtain the best radiographic reproduction of the biliary tract, criteria have been established in order to standardize interpretations, and, with the ever-increasing number of examinations, information has been accumulated to evaluate the advantages and limitations of this diagnostic procedure.
Iodipamide, being isotonic, is administered intravenously and under normal conditions is excreted promptly by the liver.
COHN EM, SKLAROFF DM. A Review of the Current Status of Nonoperative Cholecystoangiography. AMA Arch Intern Med. 1958;101(6):1051–1056. doi:10.1001/archinte.1958.00260180041005
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