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June 1958

Sarcoidosis: Study of Twenty-Nine Cases, with a Review of Splenic, Hepatic, Mucous-Membrane, Retinal, and Joint Manifestations

Author Affiliations

U. S. A. F.

AMA Arch Intern Med. 1958;101(6):1065-1084. doi:10.1001/archinte.1958.00260180055007

Since Hutchinson's1 original description of the cutaneous manifestations of sarcoidosis, its systemic nature and protean symptomatology have been thoroughly documented. The more recent contributions have helped to clarify the history, epidemiology, and many clinical and pathologic aspects of the disease.2-6

The true incidence of sarcoidosis is unknown. The increasing routine use of thoracic roentgenograms in recent years has revealed many cases in apparently normal people; a considerable percentage of these persons have remained asymptomatic while the process spontaneously resolved. During World War II, sarcoidosis was discovered in 2.1 of each 100,000 inductees to the U. S. Army.6 In the Swiss Army, Schönholzer 7 reported an incidence of 13 cases per 100,000 draftees. At Bellevue Hospital, 52 cases of sarcoidosis were seen in 10 years,8 while the combined series of The Johns Hopkins Hospital and the Massachusetts General Hospital totaled 148 cases over a 20-year period.5