The proper evaluation of the effectiveness of therapy in schistosomiasis is rendered difficult by the protean clinical manifestations of the disease, the invariable tendency toward chronicity, and the lack of accurate information pertaining to the natural course of the disease. From the outset a pessimistic attitude is assumed in view of the failure to discover drugs of definite efficacy. A review of the voluminous medical literature dealing with this subject fails to reveal a single medication that can effectively control the ravages of the disease. Thus, after maturation of the parasite and oviposition, progressive, and at times irreversible, tissue changes occur, emphasizing the early recognition of the disease as the most important governing factor in the determination of the degree of possible therapeutic success in the future. However, it appears as if the direct contact of the adult parasites and their eggs with the host's tissues leads to pathological alterations
DÍAZ-RIVERA RS, RAMOS-MORALES F, SOTOMAYOR ZR, SANTIAGO S. The Treatment of Schistosomiasis. AMA Arch Intern Med. 1958;101(6):1151–1158. doi:10.1001/archinte.1958.00260180141016
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