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July 1958

Nonspecific Granulomatous Disease of the Stomach: A Clinical Pathological Study

Author Affiliations


Department of Medicine, The University of Chicago.

AMA Arch Intern Med. 1958;102(1):10-24. doi:10.1001/archinte.1958.00260190012003

Introduction  Chronic granulomatous inflammation1 is a process initiated usually by a group of harmful agents which bring into defensive activity a specialized cellular mechanism-the reticuloendothelial system. The basic lesion, a granuloma in typical cases, contains at the periphery concentric reticular fibers, while the center is occupied by epithelioid cells, with or without giant cells. Such granulomata have been found in a variety of infections, such as tuberculosis,2 syphilis,3 and cat-scratch fever.4 Similar granulomata have been noted in sarcoidosis,5,6 in chronic ulcerative colitis, and in regional enteritis, diseases currently considered nonspecific, in view of lack of knowledge of their etiology. Granulomata are found in berylliosis,7 in silicosis,8 and in other conditions when foreign bodies have some into intimate contact with living tissue. Granulomata have been observed also as part of a local tissue response in hypersensitivity reactions produced in the experimental animal with specific