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July 1958

Studies in Myasthenia Gravis: Review of Two Hundred Eighty-Two Cases at The Mount Sinai Hospital, New York City

Author Affiliations

New York

From the Myasthenia Gravis Clinic and the Departments of Medicine and Neurology, The Mount Sinai Hospital.

AMA Arch Intern Med. 1958;102(1):72-81. doi:10.1001/archinte.1958.00260190074008

Reviewed for therapeutic results were 282 proved cases of myasthenia who were attending the Myasthenia Gravis Clinic of The Mount Sinai Hospital, New York City. Various statistical studies were presented as an exhibit, which is summarized as follows.

Patients with this illness present varying clinical pictures but with the common denominator of muscle fatigability made worse by exercise and partially reversible by rest or the administration of anticholinesterase drugs. Within this broad picture there are many variants, such as sex, age of onset, localization or spread of symptomatology, and prognosis.

Sex, Age, and Race  There were 188 female and 94 male patients, confirming the previously reported 2:1 sex ratio.1 As the clinical picture varied in the over-all group, our tendency was to segregate patients showing similar features. The sex ratio was 1:1 in the milder forms of the disease and varied from two to four females to one male

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