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July 1958

Serum Enzymes in Disease: II. Lactic Dehydrogenase and Glutamic Oxalacetic Transaminase in Anemia

Author Affiliations


From the Departments of Medicine, West Side Veterans' Administration Hospital, The Chicago Medical School, and the University of Illinois College of Medicine.

AMA Arch Intern Med. 1958;102(1):115-123. doi:10.1001/archinte.1958.00260190117013

Abnormal levels of serum enzymes have been observed in a number of diseases.1-4 Attention has been particularly devoted to the study of the serum glutamic oxalacetic transaminase levels in patients with cardiac and hepatic disease.2,3 There has been no systematic study of the serum enzymes in patients with anemia. In a study of lactic dehydrogenase levels of the serum in patients with various diseases4 it was found that the levels of this enzyme were elevated in patients with megaloblastic anemia and in those with sickle-cell disease but not in patients with a number of other types of anemia. The present study constitutes an extension of these observations. The levels of lactic dehydrogenase and glutamic oxalacetic transaminase have been studied in patients with megaloblastic anemia, hemoglobinopathies. other hemolytic anemias, and anemias of other causes.

Materials and Methods  The serum levels of lactic dehydrogenase (LD) were determined by a

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