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July 1958

The Histopathology of the Experimental Hypersensitive State in the Gastrointestinal Tract: A Critical Review

Author Affiliations


Department of Medicine, The University of Chicago.

AMA Arch Intern Med. 1958;102(1):134-148. doi:10.1001/archinte.1958.00260190136016

Introduction  There is an increasing awareness of the potential role of immunologic disorders in human disease. Recent reports1-6 suggest a hypersensitivity mechanism in diseases such as Hashimoto's disease 1 chronic thyroiditis,3 and acute hemorrhagic pancreatitis,3 acute hepatitis,4 certain instances of acute ulcerative colitis,5 acute glomerulonephritis and the nephrotic syndrome,6 sarcoidosis,7 and Whipple's disease.8,9 Whereas symptoms caused by allergic reactions were attributed originally to change in function only,10 subsequent studies have indicated conspicuous alterations in tissues, the site of a local hyperimmune state. Widespread pathological changes can be found also in the acute generalized anaphylactic reactions.11-13 Gastrointestinal hypersensitivity is rarely diagnosed clinically, however, chiefly because of the difficulty in demonstrating an antigen-antibody relationship in any given case. During recent studies on human stomach and colon tissue14,15 and in the experimental animals16 information was collected regarding hypersensitivity reactions in the gastrointestinal tract. It seemed of interest to review this material as an

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