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August 1958

Salicylate Intoxication in an Adult

Author Affiliations

Rochester, Minn.

AMA Arch Intern Med. 1958;102(2):213-216. doi:10.1001/archinte.1958.00260200041008

In 1919 Lewis1 published the first report of a case of acetylsalicylic acid poisoning in an adult in the English literature. Numerous reports of cases have been published since, but these do not reflect the true incidence, for records of the United States Bureau of the Census* reveal many more cases than the professional journals. We were able to collect from the literature in English reports of 115 instances, of which 15 were fatal. In 1952 there were 115 deaths in the United States due to salicylate poisoning of all types; 86 of them occurred in children less than 5 years old, and 41 of the deaths were due to acetylsalicylic acid.3 Robin4 reported the case of a patient who ingested 2500 grains of acetylsalicylic acid in a suicide attempt. The patient vomited four hours later and was lavaged three hours after vomiting, and so probably not

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