It has long been known that many actions of hormones are not direct but are due to the creation of favorable conditions for the actions of nonhormonal agents.1 In our institute this phenomenon of "conditioning" by hormones of the sensitivity to nonendocrine stimuli has been studied, particularly in relation to the actions of electrolytes. It was found, for example, that the production of nephrosclerosis, myocarditis, and periarteritis nodosa by deoxycorticosterone does not depend upon the direct effects of the hormone but upon its ability to sensitize tissues to dietary sodium chloride.2,3 Apparently, it is through an essentially similar mechanism that deoxycorticosterone produces favorable conditions for the production of nephrocalcinosis, by the concurrent administration of, in themselves, inactive doses of phosphate.4
A particularly striking instance of the selective conditioning of cardiac tissue for the toxic actions of dietary sodium phosphates (NaH2PO4 and Na2HPO has recently come to our attention. Rats treated
SELYE H, SALCEDO ID. "Infarctoid Cardiopathy" Produced by Hydrocortisone and Monobasic Sodium Phosphate. AMA Arch Intern Med. 1958;102(4):551–557. doi:10.1001/archinte.1958.00260210037006
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