Certain of the blood-clotting factors have a number of properties in common. These properties include affinity for the insoluble salts of heavy metals (i. e., barium sulfate), relative heat lability and storage stability, and lack of utilization during the course of clotting. The last-named property, whereby serum contains these factors in undiminished titer, has led some investigators to use the term "serum factors." The presently accepted "serum factors" are Factor VII, plasma thromboplastin component (PTC), and Stuart factor.1
Except for its utilization during clotting, prothrombin shares the above-mentioned properties of the "serum factors." These similarities have suggested the "serum factors" are derivatives of or share a common synthetic pathway with prothrombin. Evidence for this view has been provided by the finding that all are depressed following administration of bishydroxycoumarin (Dicumarol) and related drugs,2-5 suggesting that vitamin K is necessary for their synthesis. Moreover, it has been possible to
SPAET TH, KROPATKIN M. Studies on "Prothrombin Derivatives" in Vitamin K Deficiency. AMA Arch Intern Med. 1958;102(4):558–561. doi:https://doi.org/10.1001/archinte.1958.00260210044007
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: