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October 1958

Studies on "Prothrombin Derivatives" in Vitamin K Deficiency

Author Affiliations

New York

From the Department of Hematology, Division of Laboratories, Montefiore Hospital.

AMA Arch Intern Med. 1958;102(4):558-561. doi:10.1001/archinte.1958.00260210044007

Certain of the blood-clotting factors have a number of properties in common. These properties include affinity for the insoluble salts of heavy metals (i. e., barium sulfate), relative heat lability and storage stability, and lack of utilization during the course of clotting. The last-named property, whereby serum contains these factors in undiminished titer, has led some investigators to use the term "serum factors." The presently accepted "serum factors" are Factor VII, plasma thromboplastin component (PTC), and Stuart factor.1

Except for its utilization during clotting, prothrombin shares the above-mentioned properties of the "serum factors." These similarities have suggested the "serum factors" are derivatives of or share a common synthetic pathway with prothrombin. Evidence for this view has been provided by the finding that all are depressed following administration of bishydroxycoumarin (Dicumarol) and related drugs,2-5 suggesting that vitamin K is necessary for their synthesis. Moreover, it has been possible to

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