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November 1958

Hodgkin's Disease and Pregnancy: Case Reports and a Discussion of the Treatment of Hodgkin's Disease and Leukemia During Pregnancy

AMA Arch Intern Med. 1958;102(5):777-789. doi:10.1001/archinte.1958.00260220093009

Introduction  Hodgkin's disease complicated by pregnancy constitutes a situation in which the mother is burdened by two proliferating systems, the disease and the fetus. One demands elimination or control; the other, preservation. During the past year we were confronted by this problem six times, and on several occasions treatment was urgently indicated. We reviewed the subject to learn the experience of others. Numerous papers were available on the influence of pregnancy on Hodgkin's disease and the question of therapeutic abortion, but little information was found relevant to the problem of control of the disease and preservation of the fetus when therapy is demanded. Irradiation has been employed frequently, but the chemotherapeutic agents have not been used sufficiently to permit adequate evaluation of their effect on pregnancy. It is advisable to use the antimetabolites and alkylating agents and, if so, when during pregnancy are they least harmful to the fetus? The

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