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December 1958

An Analysis of Some Features of Renal Tubular Dysfunction

Author Affiliations

Chapel Hill, N. C.

From the Department of Medicine, University of North Carolina School of Medicine.

AMA Arch Intern Med. 1958;102(6):881-890. doi:10.1001/archinte.1958.00260230027005

A number of renal disorders which differ from those most commonly seen in clinical medicine have received wide attention during the last three decades. Prominent among these is a group of diseases or syndromes characterized by abnormalities which can be traced primarily to impairment of one to several functions of the renal tubules, including those associated with abnormalities of cation excretion, especially of potassium and calcium. It is the purpose of this report to consider some current concepts of the abnormal mechanisms operating in some of the better-studied syndromes in this group of renal diseases, to suggest possible relationships between some of them, and especially to attempt to identify areas where further experimental observations are necessary. Management in most instances has become fairly well standardized; one would anticipate little change until more fundamental understanding of their pathogenesis is achieved. No attempt will be made to discuss the syndromes completely, since

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