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January 1959

The Indeterminate Pulmonary Infiltration—Our Diagnostic Dilemma: Report of Twenty-Three Cases of Chronic Granulomatous Disease of the Lung

Author Affiliations

Covina, Calif.; Indianapolis; U. S. Army

From the Pulmonary Medical and Surgical Departments and Pathology Service, Valley Forge Army Hospital, Phoenixville, Pa. Present address, Pathology Department, Indiana University Medical Center (Dr. Schulz).

AMA Arch Intern Med. 1959;103(1):23-27. doi:10.1001/archinte.1959.00270010029005

The accurate diagnosis of the indeterminate pulmonary infiltration remains a difficult clinical and pathological problem. The increased use of pulmonary biopsy and resection has, in many instances, led to the correct diagnosis. However, in many other clinically similar cases, the exact diagnosis sill remains obscure even after biopsy. The purpose of this report is to analyze 23 cases of granuloma of the lung that presented as indeterminate pulmonary infiltrations. It is hoped that this analysis will demonstrate the similar clinical pattern of the various fungus and granulomatous diseases of the lung, the variability of laboratory aids, the important role that surgery plays in both a positive and a negative sense, and the increasing need for finer and more accurate methods of diagnosis. By its very nature, this paper is also a further plea to clinicians to exhaust all available diagnostic methods, including surgery, before committing any given patient to a

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