[Skip to Navigation]
January 1959

Thymoma and Hemopoietic Insufficiency

Author Affiliations


From the Departments of Pathology, University of Pittsburgh and Veterans' Administration Hospital.

AMA Arch Intern Med. 1959;103(1):95-104. doi:10.1001/archinte.1959.00270010101013

The association of thymic neoplasms with myasthenia gravis is well recognized. A thymoma has been encountered in approximately one-fourth of the patients with this disorder, and a large number exhibit microscopic evidence of hyperplasia of this structure.1 More than 50% of thymic neoplasms have occurred in persons with myasthenia gravis.2 The exact relationship of this association is baffling. Resection of a thymoma in patients with this disorder has resulted in the alleviation of its clinical manifestations in some but not all instances, and examples of myasthenia gravis developing after the removal of such a tumor have accumulated in the literature.3 One of the cases reported by Fisher, Coburn, and Effler 4 was unique in that the development of a thymoma provided relief from the symptoms of myasthenia gravis which had been present for 13 years.

In recent years attention has been directed to the occurrence of thymic

Add or change institution