The principle of explaining all of the symptoms and findings of a patient as manifestations of the same disease entity is undoubtedly justified in the majority of cases. All physicians are familiar with exceptions to the rule, particularly in older patients in whom multiple diagnoses are not uncommon. Indeed, the early recognition of two major diseases in the same patient presents a real challenge, particularly if both major diseases involve the same organ.
Coexistence of pulmonary tuberculosis and carcinoma of the lung is well known. In the cases reported a common feature is the late diagnosis of the neoplasm, with a paucity of survivals because the carcinoma is so far advanced that successful treatment cannot be applied. Moreover, many cases are recognized only at postmortem examination.
Famous pathologists have tried to correlate the etiology of the two diseases in one way or another and sometimes in exactly opposite ways. Rokitansky
CHRISTOFORIDIS AJ, BROWNING RH. Pulmonary Tuberculosis Associated with Carcinoma of the Lung. AMA Arch Intern Med. 1959;103(2):231–238. doi:10.1001/archinte.1959.00270020059007
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