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February 1959

The Hemophilioid States: The Practical Application of Present-Day Concepts of Blood Coagulation to Diagnosis and Treatment

Author Affiliations

charlottesville, Va.

From the Department of Clinical Pathology, University of Virginia School of Medicine.

AMA Arch Intern Med. 1959;103(2):239-252. doi:10.1001/archinte.1959.00270020067008

During the past decade there has developed an aura of growing alarm and bewilderment at the progressive complexity of blood coagulation concepts. In the face of this concern, it would seem desirable to review briefly the nature of these concepts and to discuss their practical applications in general medical practice, with particular emphasis on the hemophilioid states.

The hemorrhagic disorders may be divided into three etiologic groups.

Etiologic Groups of Hemorrhagic Disorders  Congenital Hemophilioid Disorders1-21 (Table 1).These are ordinarily understood to be hemorrhagic disorders that clinically resemble hemophilia resulting from a genetically determined deficiency or inactivity of a factor in plasma which is necessary for an effective prothrombin-converting and fibrin-forming mechanism.1In this communication hemophilia will be included under the heading of a congenital hemophilioid state, although this is not strictly in accord with the common usage of this term. Acquired hemorrhagic states22-35 closely resembling hemophilia

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