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May 1959

Carbohydrate Metabolism in Brain DiseaseXII. Effects of Epinephrine on Intermediary Carbohydrate Metabolism in Normal and Schizophrenic Subjects

AMA Arch Intern Med. 1959;103(5):730-738. doi:10.1001/archinte.1959.00270050052009

Abnormalities in carbohydrate metabolism that occur in patients with schizophrenic manic-depressive, and involutional psychoses have been described in earlier communications from this laboratory.1-4 In psychotic subjects the administration of glucose is frequently followed by excessive or prolonged elevations of blood levels of glucose, lactate pyruvate, citrate, and α-ketoglutarate in psychotic subjects. However, these abnormalities are not specific, since they occur in various other diseases.

Since there is evidence that there is increased secretion of both cortical and medullary hormones of the adrenal glands in mental disorders,5 it seemed likely that some of the abnormalities of carbohydrate metabolism of psychotic patients might be caused or at least modified by the action of these substances. Earlier work, done at this hospital,3 showed that hydrocortisone caused elevations of blood levels of glucose, lactate, and pyruvate after administration of glucose greater than those found in the same subjects not under the

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