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May 1959

The Diuretic Response to Administered Water in Patients with Liver Disease: I. Acute Infectious Hepatitis

Author Affiliations


From the Medical Service, Boston Veterans Administration Hospital, and the Departments of Medicine, Boston University School of Medicine and Tufts University School of Medicine. Assistant Chief of the Medical Service, Boston Veterans Administration Hospital, and Associate Clinical Professor of Medicine, Tufts University School of Medicine (Dr. Papper); present address, Lakewood, Calif. (Dr. Seifer); work done during the tenure of a United States Public Health Service Postdoctorate Research Fellowship in Medicine (Dr. Saxon).

AMA Arch Intern Med. 1959;103(5):746-749. doi:10.1001/archinte.1959.00270050068011

The extensive literature concerned with the urinary excretion of water and solute in patients with liver disease has recently been reviewed.1 Although many reports describe impairment of water excretion in acute infectious hepatitis,2-5 there are few observations concerned with the determination of maximal diuretic response to administered water in conjunction with measurement of glomerular filtration rate and solute excretion. Accordingly, the acute renal response to water loading was investigated in ten patients with active viral hepatitis. In all, during the acute phase of the disease, a normal diuretic response to water administration was demonstrated.

Material and Methods  The patients, men varying in age from 21-34, were studied during the acute phase of viral hepatitis as diagnosed by clinical and laboratory criteria. Certain relevant data concerning the patients are shown in Table 1. Eight of the patients were studied within three days of admission before any improvement in clinical