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June 1959

The Syndrome of Chronic Pulmonary Disease and Gastroduodenal Ulceration: A Clinical Study and Literature Review

Author Affiliations

Columbus, Ohio; Huntington, W. Va.; Charleston, W. Va.

From the Department of Internal Medicine, Memorial Hospital, Charleston, W. Va. Senior Assistant Resident in Medicine (Hematology), The Ohio State University (Dr. West).

AMA Arch Intern Med. 1959;103(6):897-901. doi:10.1001/archinte.1959.00270060049007

Introduction  This hospital located in the heart of West Virginia's coal industry has an unusually large number of patients with chronic pulmonary disease. The recent literature contains several articles suggesting an increased incidence of gastroduodenal ulceration in these patients.1-3We have had the clinical impression that patients with chronic pulmonary disease tend to have gastroduodenal ulceration more frequently than would be anticipated in the general population. To justify this impression, this study is presented.

Material and Method  The charts of all patients admitted to the medical teaching service from January, 1955, through April, 1958, were reviewed. There were 845 patients. This was considered a random sampling of general medical patients. The following information was abstracted from the records: (1) age, race, and sex; (2) symptoms, signs, x-ray, electrocardiographic, and laboratory evidence of chronic pulmonary disease,* and (3) symptoms, complications, and x-ray evidence of gastroduodenal ulceration.†Many of these

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